|
KMID : 1003219980040010203
|
|
Journal of Korean Oriental Chronic Disease
1998 Volume.4 No. 1 p.203 ~ p.209
|
|
|
Effeet of Cerebral Ischemia on Sex Hormonal Alteration in Ovarectomized Rats
|
|
|
|
|
Abstract
|
|
|
The aim of this study was to assess ischemic effect on sex hormonal alteration(17β-estradiol, LH, FSH) in ovarectomized rats.
Rats were divided into 3 groups ; normal group(n=10), ovariectomized group without cerebral ischemia(OV group, n=10), and ovariectomized group with cerebral ischemia (OVCI group, n=10).
Sex hormons in both ovariectomized groups were determined on 15th day(n=5) and 30th (n=5) after ovariectomy. For normal data and its comparison , the same numbers of rat in normal group were killed on the same day. Cerbral ischemia was induced by electrocauterization of rhinal fissure portion of left middle cerebral artery and 1 hour ligation of both common carotid artery. After 1 hour ligation, right common carotid artery was reperfusioned and left artery was occluded permantly. after finishing ischemia, rats were returned to their cages.
It have been found that concentration of 17β-estradiol, LH,and FSH were more lower in the cerebral ischemia treated ovariectomized group than in the non treated ovariectomized (p<0.05)
This study shows that cerebral ischemic injury can inhibit the compensatory function of adrenal gland on estrogen production and that also impair the hypothalmus and hypophysis functions in the ovariectomized rats.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|